Ausgewählte Publikationen

Triac Treatment Prevents Neurodevelopmental and Locomotor Impairments in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice.
Chen J, Salveridou E, Liebmann L, Sundaram SM, Doycheva D, Markova B, Hübner CA, Boelen A, Visser WE, Heuer H, Mayerl S.
2023. Int. J. Mol. Sci. doi: 10.3390/ijms24043452

Gene therapy targeting the blood-brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency.
Sundaram SM, Arrulo Pereira A, Müller-Fielitz H, Köpke H, De Angelis M, Müller TD, Heuer H, Körbelin J, Krohn M, Mittag J, Nogueiras R, Prevot V, Schwaninger M.
2022. Brain. doi: 10.1093/brain/awac243 

AAV9-MCT8 delivery at juvenile stage ameliorates neurological and behavioral deficits in a mouse model of MCT8-deficiency.
Liao XH, Avalos P, Shelest O, Ofan R, Shilo M, Bresee C, Likhite S, Vit JP, Heuer H, Kaspar B, Meyer K, Dumitrescu AM, Refetoff S, Svendsen CN, Vatine GD. 
2022. Thyroid doi: 10.1089/thy.2022.0034

Distinct actions of the thyroid hormone transporters Mct8 and Oatp1c1 in murine mouse adult hippocampal neurogenesis.
Mayerl S, Alcaide Martin A, Bauer R, Schwaninger M, Heuer H^#, ffrench-Constant C^#. ^#Contributed equally.
2022. Cells 11(3):524. doi: 10.3390/cells11030524

Thyroid Hormone Transporter Deficiency in Mice Impacts Multiple Stages of GABAergic Interneuron Development.
Mayerl S, Chen J, Salveridou E, Boelen A, Darras VM, Heuer H.
2022. Cereb Cortex 32(2):329-341. doi: 10.1093/cercor/bhab211

TRIP6 functions in brain ciliogenesis.
Shukla S, Haenold R^#, Urbánek P^#, Frappart L, Monajembashi S, Grigaravicius P, Nagel S, Min WK, Tapias A, Kassel O, Heuer H, Wang ZQ, Ploubidou A, Herrlich P. ^#Contributed equally.
2021. Nat Commun 12(1):5887. doi: 10.1038/s41467-021-26057-6

Oligodendrocyte progenitor cell maturation is dependent on dual function of MCT8 in the transport of thyroid hormone across brain barriers and the plasma membrane.
Vatine GD, Shelest O, Barriga BK, Ofan R, Rabinski T, Mattis VB, Heuer H, Svendsen CN.
2021. Glia 69(9):2146-2159. doi: 10.1002/glia.24014

Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone.
Luongo C, Butruille L, Sébillot A, Le Blay K, Schwaninger M, Heuer H, Demeneix AH, Remaud S.
2021. Stem Cell Reports 16(2):337-353. doi: 10.1016/j.stemcr.2020.12.009

Brain Gene Expression in Systemic Hypothyroidism and Mouse Models of MCT8 Deficiency: The Mct8-Oatp1c1-Dio2 Triad.
Morte B, Gil-Ibañez P, Heuer H, Bernal J.
2021. Thyroid 31(6):985-993. doi: 10.1089/thy.2020.0649

Hippocampal neurogenesis requires cell-autonomous thyroid hormone signaling.
Mayerl S, Heuer H, ffrench-Constant C.
2020. Stem Cell Reports 14(5):845-860. doi: 10.1016/j.stemcr.2020.03.014

Thyroid Hormone Transporters.
Groeneweg S, van Geest FS, Peeters RP, Heuer H, Visser WE.
2020. Endocr Rev 41(2):bnz008. doi: 10.1210/endrev/bnz008

Thyroid hormone transporters Mct8 and Oatp1c1 control skeletal muscle regeneration.
Mayerl S, Schmidt M, Darras VM, Hüttner SS, Boelen A, Visser TJ; Kaether C, Heuer H^#, von Maltzahn J^#. ^#Contributed equally.
2018. Stem Cell Reports 10(6):1959-1974. doi: 10.1016/j.stemcr.2018.03.021

In vitro and mouse studies supporting therapeutic utility of triiodothyroacetic acid in MCT8 deficiency.
Kersseboom S, Horn S, Visser WE, Chen J, Friesema ECH, Vaurs-Barrière C, Peeters RP, Heuer H^#, Visser TJ^#. ^#Contributed equally.
2014. Mol Endocrinol 28(12):1961-70. doi: 10.1210/me.2014-1135

Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.
Mayerl S, Müller J, Bauer R, Richert S, Kassmann CM, Darras VM, Buder K, Boelen A, Visser TJ, Heuer H.
2014. J Clin Invest 124(5):1987-99. doi: 10.1172/JCI70324

Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8.
Trajkovic M, Visser TJ, Mittag J, Horn S, Lukas J, Darras VM, Raivich G, Bauer K, Heuer H.
2007. J Clin Invest 117(3):627-35. doi: 10.1172/JCI28253